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Abstract: Cancer causes the cells of the body to shatter their well-defined roles, proliferate, and invade other tissues, leading to premature death. As a lapsed mathematician turned bioengineer, I lead a research group that studies cancer to propose novel therapies based on the spatial structure of tumor tissue. While there is no such thing as a "topological combinatorial construct" as far as I know, there is great significance in how different cells in our body are positioned in space and relative to each other. Our modern understanding of cancer proposes that a complex network of biological signals, partitioned into various cell types, is the fabric that frays and eventually dissolves in cancer. The functions woven into this fabric include immune cell control of diseased cells, secreted signals that attract and repel cells, and even a physical meshwork of collagenous and fibrotic material that impedes tumor and immune migration. Currently, my lab uses spatial molecular tools that can measure dozens of proteins and thousands of RNA biomolecules directly within intact tissue, allowing us to reconstruct the physical cellular architecture of tumors. We can use this information to characterize tumor tissue in depth and identify structures with predictive significance, based on the spatial cellular organization. However, the tools that we use to describe tumor structures are still simplistic, and our vocabulary is still limited when describe interacting fields of objects with hundreds to thousands of signals and properties. My goals for this seminar are to first present the structure and language of spatial biology data and its current applications, and then to recruit your minds to capture the underlying structures, patterns, and projections that will allow us to translate spatial data into actionable hypotheses to improve the treatment of cancer.